"neutrophil function in 8 cases of papillon-lefevre syndrome "

statement of problem: papillon lefevre syndrome (pls) is a rate autosomal recessive disorder, which is characterized by palmar- plantar hyperkeratosis and rapid periodontal destruction of primary and permanent dentitions. purpose: the aim of the present study was to evaluate the peripheral blood neutrophil function including random locomotion, chemotaxis and oxidative mechanism of killing in a group of patients with pls. materials and methods: peripheral blood was obtained from 8 pls patients and 92 healthy control subjects. pmn mobility was measured by a modification of the micromethod of addison and babbage. latex-stimulated nbt reduction test described by park et al was followed. data were analyzed by mann whitney u test. results: the chemotactic activity in the pls group was significantly lower than control group (89.5±21.6 vs 113±16 m, p 0.05). conclusion: the present study indicated an impaired neutrophil chemotaxis in pls patients.